Intravenous Drug Stability
  Stability  
Medication Refrigeration (4-5o C) Room Temperature Diluent Comments
Abciximab (Reopro) 24 hours 24 hours D5W, NS Filtered through 0.22 micron filter
Acetazolamide (Diamox) 44 days 5 days D5W, NS  
Acyclovir (Zovirax) 35 days* 21 days(D5W)/7 days (NS) D5W, NS * - Use immediately when at room temp;1,7,10mcg/ml
Amikacin 60 days* 24 hours D5W, NS * - Use immediately when at room temp
Amiodarone (Cordarone) 32 days* 24 hours D5W * - 2mg/ml conc; filter with 0.22 micron filter
Amphotericin B   24 hours D5W 100mcg/ml concentration
Amphotericin B Liposomal 24 hours   D5W use immediately after preparation
Ampicillin 5 days(NS)/4 hours (D5W) 24 hours(NS)/2 hours (D5W) D5W, NS  
Azithromycin (Zithromax) 7 days 24 hours D5W, NS 1-2mg/ml concentration
Aztreonam (Azactam) 7 days 48 hours NS  
Bretylium 7 days 48 hours D5W, NS maximum concentration 10mg/ml
Bumetanide (Bumex) 72 hours   D5W 0.02-0.2mg/ml concentration
Bupivacaine 7 days 4 days NS  
Cefazolin (Kefzol) 96 hours 24 hours D5W 10mg/ml concentration
Cefepime (Maxipime) 21 days 48 hours NS 20mg/ml concentration
Cefotaxime 10 days 24 hours D5W  
Cefotetan (Cefotan) 96 hours 24 hours D5W, NS  
Cefoxitin 48 hours 24 hours D5W, NS  
Ceftazidime (Fortaz) 7 days 18 hours D5W, NS  
Ceftizoxime (Ceftizox) 7 days(NS)/5 days (D5W) 48 hours D5W, NS  
Ceftriaxone (Rocephin) 7 days 12 hours D5W, NS 2g/50ml concentration
Ciprofloxacin (Cipro) 14 days 14 days D5W, NS 0.5-2mg/ml concentration
Cisatracurium 24 hours 24 hours D5W, NS 0.1mg/ml concentration
Clindamycin (Cleocin) 54 days 22 days D5W, NS  
Dexamethasone (Decadron) 28 days 28 days NS  
Digoxin 48 hours 48 hours D5W, NS  
Diltiazem (Cardizem) 24 hours 24 hours D5W, NS 1mg/ml concentration
Diphenhydramine (Benadryl) 91 days 91 days D5W, NS 12.5-50mg/ml concentration; protect from light
Dobutamine 30 days 30 days D5W 4mg/ml concentration
Dopamine 14 days 48 hours D5W, NS  
Doxycycline   48 hours D5W, NS 0.1-1mg/ml concentration; protect from light
Enalaprilat (Vasotec)   24 hours D5W, NS  
Epinephrine (Adrenalin)   24 hours D5W 0.1mg/ml concentration; protect from light
Ertapenem (Invanz)   4 hours NS reconstituted vials stable for 24 hours
Erythromycin (Erythrocin)   8 hours D5W vials stabile reconstituted for 2 weeks refrigerated
Esmolol (Brevibloc) 168 hours* 48 hours** D5W, NS *-10mg/ml concentration;**-10-30mg/ml concentration
Famotidine (Pepcid) 14 days 48 hours D5W, NS 200mcg/ml concentration
Fentanyl   48 hours D5W, NS 4.2-4.5mcg/ml concentration
Fluconazole (Diflucan)   72 hours D5W 2mg/ml concentration
Fosphenytoin (Cerebryx) 24 hours 8 hours D5W, NS 1.5-25 PE/ml concentration
Furosemide (Lasix)       D5W causes precipitates
Gentamicin (Garamycin)   24 hours D5W, NS  
Haloperidol (Haldol)   38 days D5W 10mg/ml concentration
Heparin 96 hours   D5W, NS  
Hydrocortisone (Solu-Cortef) 21 days 7 days NS 10mg/ml concentration
Hydromorphone (Dilaudid)   24 hours D5W, NS 80mg/L concentration
Imipenem (Primaxin) 48 hours 10 hours NS  
Inamrinone (Inocor)   24 hours NS  
Insulin-R 24 hours 24 hours D5W, NS  
Itraconazole (Sporanox) 48 hours 48 hours NS 3.33mg/ml concentration
Labetalol (Trandate, Normodyne) 72 hours 72 hours D5W, NS 1.25-3.75mg/ml concentration
Levofloxacin (Levaquin) 14 days 72 hours D5W 5mg/ml concentration
Lidocaine   7 days NS up to 0.25% concentration
Lorazepam (Ativan)   24 hours D5W 1mg/ml concentration
Magnesium Sulfate   3 months NS  
Meperidine (Demerol) 28 days 28 days D5W, NS 0.25-30mg/ml concentration
Meropenem (Merrem) 4 hours(D5W)/24 hours(NS) 1 hour(D5W)/4 hours (NS) D5W, NS 1-20mg/ml concentration
Methadone   4 weeks NS 1-5mg/ml concentration
Methotrexate 14 days 7 days NS 25mg/ml concentration
Methyldopate 24 hours 24 hours D5W, NS  
Methylprednisolone (Solu-Medrol)   24 hours D5W, NS D5W: 0.5-1% conc./NS: 1 or 5% conc.
Metoclopramide (Reglan)   48 hours NS Stable frozen for 4 weeks in NS
Metoprolol (Lopressor)   36 hours D5W, NS 0.4mg/ml concentration
Metronidazole (Flagyl)   24 hours D5W must add 5meq of Na Bicarbonate to each 500mg
Midazolam (Versed)   10 days NS 1mg/ml concentration; protect from light
Milrinone (Primacor) 14 days 14 days D5W, NS 200-800mcg/ml concentration
Minocycline (Minocin)   24 hours D5W, NS 100mg/50ml concentration
Morphine sulfate 12 days 12 days NS 2 and 15mg/ml concentration
Nafcillin   24 hours NS  
Naloxone (Narcan)   24 hours D5W, NS  
Nitroglycerin   24 hours D5W, NS  
Nitroprusside (Nipride)   24 hours D5W must be protected from light
Norepinephrine (Levophed)   24 hours D5W 64mcg/ml concentration
Ondansetron (Zofran)   7 days D5W, NS  
Pancuronium   48 hours D5W, NS 40mg/500ml concentration
Penicillin-G Potassium 24 hours 24 hours D5W, NS must buffer solution (pH 6-7)
Phenobarbital 4 weeks   NS 10mg/ml concentration
Phenylephrine (Neo-synephrine) 48 hours 48 hours D5W, NS  
Phenytoin (Dilantin) 4 hours 4 hours NS maximum rate 50mg/min; filter with 0.22 micron filter
Piperacillin 1 week 24 hours D5W, NS  
Piperacillin-Tazobactam (Zosyn) 28 days/7 days 2 days/2 days D5W, NS premixed bags/admixed bags
Potassium Chloride 24 hours 24 hours D5W, NS  
Procainamide 24 hours 24 hours D5W, NS  
Prochlorperazine (Compazine) 24 hours 24 hours D5W, NS  
Rifampin (Rifadin)   24 hours D5W, NS D5W preferred
Sodium Bicarbonate 24 hours 24 hours D5W, NS  
Ticarcillin   72 hours D5W, NS 10-50mg/ml concentration
Tirofiban (Aggrastat)   24 hours D5W, NS 0.05mg/ml concentration
Tobramycin 48 hours 48 hours D5W, NS 1.17mg/ml concentration
Trimethoprim-Sulfamethoxazole     D5W, NS stability concentration dependant (see below)
Valproate   24 hours D5W, NS  
Vancomycin (Vancocin) 63 days 17 days D5W, NS 5mg/ml concentration
Vasopressin   24 hours D5W, NS  
Vecuronium (Norcuron) 24 hours      
For Bactrim - 1:25 solution (48 hours); 1:20 solution (24 hours); 1:15 solution (4 hours(D5W)/2 hours(NS)); 1:10 solution (1 hour)
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