Intravenous Drug Stability


	Stability
Medication	Refrigeration (4-5^o C)		Room Temperature	Diluent	Comments
Abciximab (Reopro)	24 hours		24 hours	D5W, NS	Filtered through 0.22 micron filter
Acetazolamide (Diamox)	44 days		5 days	D5W, NS
Acyclovir (Zovirax)	35 days*		21 days(D5W)/7 days (NS)	D5W, NS	* - Use immediately when at room temp;1,7,10mcg/ml
Amikacin	60 days*		24 hours	D5W, NS	* - Use immediately when at room temp
Amiodarone (Cordarone)	32 days*		24 hours	D5W	* - 2mg/ml conc; filter with 0.22 micron filter
Amphotericin B			24 hours	D5W	100mcg/ml concentration
Amphotericin B Liposomal	24 hours			D5W	use immediately after preparation
Ampicillin	5 days(NS)/4 hours (D5W)		24 hours(NS)/2 hours (D5W)	D5W, NS
Azithromycin (Zithromax)	7 days		24 hours	D5W, NS	1-2mg/ml concentration
Aztreonam (Azactam)	7 days		48 hours	NS
Bretylium	7 days		48 hours	D5W, NS	maximum concentration 10mg/ml
Bumetanide (Bumex)	72 hours			D5W	0.02-0.2mg/ml concentration
Bupivacaine	7 days		4 days	NS
Cefazolin (Kefzol)	96 hours		24 hours	D5W	10mg/ml concentration
Cefepime (Maxipime)	21 days		48 hours	NS	20mg/ml concentration
Cefotaxime	10 days		24 hours	D5W
Cefotetan (Cefotan)	96 hours		24 hours	D5W, NS
Cefoxitin	48 hours		24 hours	D5W, NS
Ceftazidime (Fortaz)	7 days		18 hours	D5W, NS
Ceftizoxime (Ceftizox)	7 days(NS)/5 days (D5W)		48 hours	D5W, NS
Ceftriaxone (Rocephin)	7 days		12 hours	D5W, NS	2g/50ml concentration
Ciprofloxacin (Cipro)	14 days		14 days	D5W, NS	0.5-2mg/ml concentration
Cisatracurium	24 hours		24 hours	D5W, NS	0.1mg/ml concentration
Clindamycin (Cleocin)	54 days		22 days	D5W, NS
Dexamethasone (Decadron)	28 days		28 days	NS
Digoxin	48 hours		48 hours	D5W, NS
Diltiazem (Cardizem)	24 hours		24 hours	D5W, NS	1mg/ml concentration
Diphenhydramine (Benadryl)	91 days		91 days	D5W, NS	12.5-50mg/ml concentration; protect from light
Dobutamine	30 days		30 days	D5W	4mg/ml concentration
Dopamine	14 days		48 hours	D5W, NS
Doxycycline			48 hours	D5W, NS	0.1-1mg/ml concentration; protect from light
Enalaprilat (Vasotec)			24 hours	D5W, NS
Epinephrine (Adrenalin)			24 hours	D5W	0.1mg/ml concentration; protect from light
Ertapenem (Invanz)			4 hours	NS	reconstituted vials stable for 24 hours
Erythromycin (Erythrocin)			8 hours	D5W	vials stabile reconstituted for 2 weeks refrigerated
Esmolol (Brevibloc)	168 hours*		48 hours**	D5W, NS	-10mg/ml concentration;*-10-30mg/ml concentration
Famotidine (Pepcid)	14 days		48 hours	D5W, NS	200mcg/ml concentration
Fentanyl			48 hours	D5W, NS	4.2-4.5mcg/ml concentration
Fluconazole (Diflucan)			72 hours	D5W	2mg/ml concentration
Fosphenytoin (Cerebryx)	24 hours		8 hours	D5W, NS	1.5-25 PE/ml concentration
Furosemide (Lasix)					D5W causes precipitates
Gentamicin (Garamycin)			24 hours	D5W, NS
Haloperidol (Haldol)			38 days	D5W	10mg/ml concentration
Heparin	96 hours			D5W, NS
Hydrocortisone (Solu-Cortef)	21 days		7 days	NS	10mg/ml concentration
Hydromorphone (Dilaudid)			24 hours	D5W, NS	80mg/L concentration
Imipenem (Primaxin)	48 hours		10 hours	NS
Inamrinone (Inocor)			24 hours	NS
Insulin-R	24 hours		24 hours	D5W, NS
Itraconazole (Sporanox)	48 hours		48 hours	NS	3.33mg/ml concentration
Labetalol (Trandate, Normodyne)	72 hours		72 hours	D5W, NS	1.25-3.75mg/ml concentration
Levofloxacin (Levaquin)	14 days		72 hours	D5W	5mg/ml concentration
Lidocaine			7 days	NS	up to 0.25% concentration
Lorazepam (Ativan)			24 hours	D5W	1mg/ml concentration
Magnesium Sulfate			3 months	NS
Meperidine (Demerol)	28 days		28 days	D5W, NS	0.25-30mg/ml concentration
Meropenem (Merrem)	4 hours(D5W)/24 hours(NS)		1 hour(D5W)/4 hours (NS)	D5W, NS	1-20mg/ml concentration
Methadone			4 weeks	NS	1-5mg/ml concentration
Methotrexate	14 days		7 days	NS	25mg/ml concentration
Methyldopate	24 hours		24 hours	D5W, NS
Methylprednisolone (Solu-Medrol)			24 hours	D5W, NS	D5W: 0.5-1% conc./NS: 1 or 5% conc.
Metoclopramide (Reglan)			48 hours	NS	Stable frozen for 4 weeks in NS
Metoprolol (Lopressor)			36 hours	D5W, NS	0.4mg/ml concentration
Metronidazole (Flagyl)			24 hours	D5W	must add 5meq of Na Bicarbonate to each 500mg
Midazolam (Versed)			10 days	NS	1mg/ml concentration; protect from light
Milrinone (Primacor)	14 days		14 days	D5W, NS	200-800mcg/ml concentration
Minocycline (Minocin)			24 hours	D5W, NS	100mg/50ml concentration
Morphine sulfate	12 days		12 days	NS	2 and 15mg/ml concentration
Nafcillin			24 hours	NS
Naloxone (Narcan)			24 hours	D5W, NS
Nitroglycerin			24 hours	D5W, NS
Nitroprusside (Nipride)			24 hours	D5W	must be protected from light
Norepinephrine (Levophed)			24 hours	D5W	64mcg/ml concentration
Ondansetron (Zofran)			7 days	D5W, NS
Pancuronium			48 hours	D5W, NS	40mg/500ml concentration
Penicillin-G Potassium	24 hours		24 hours	D5W, NS	must buffer solution (pH 6-7)
Phenobarbital	4 weeks			NS	10mg/ml concentration
Phenylephrine (Neo-synephrine)	48 hours		48 hours	D5W, NS
Phenytoin (Dilantin)	4 hours		4 hours	NS	maximum rate 50mg/min; filter with 0.22 micron filter
Piperacillin	1 week		24 hours	D5W, NS
Piperacillin-Tazobactam (Zosyn)	28 days/7 days		2 days/2 days	D5W, NS	premixed bags/admixed bags
Potassium Chloride	24 hours		24 hours	D5W, NS
Procainamide	24 hours		24 hours	D5W, NS
Prochlorperazine (Compazine)	24 hours		24 hours	D5W, NS
Rifampin (Rifadin)			24 hours	D5W, NS	D5W preferred
Sodium Bicarbonate	24 hours		24 hours	D5W, NS
Ticarcillin			72 hours	D5W, NS	10-50mg/ml concentration
Tirofiban (Aggrastat)			24 hours	D5W, NS	0.05mg/ml concentration
Tobramycin	48 hours		48 hours	D5W, NS	1.17mg/ml concentration
Trimethoprim-Sulfamethoxazole				D5W, NS	stability concentration dependant (see below)
Valproate			24 hours	D5W, NS
Vancomycin (Vancocin)	63 days		17 days	D5W, NS	5mg/ml concentration
Vasopressin			24 hours	D5W, NS
Vecuronium (Norcuron)	24 hours

For Bactrim - 1:25 solution (48 hours); 1:20 solution (24 hours); 1:15 solution (4 hours(D5W)/2 hours(NS)); 1:10 solution (1 hour)

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