Drug Hemodialysis CAPD
Analgesics
Meperidine Negligible Negligible
Methadone Negligible (1%) Negligible (1%)
Nalmefene Negligible (3.3%) ---
Propoxyphene Negligible Negligible
Salicylates Negligible Negligible
Tilidine Negligible (< 1%) ---
Tramadol Negligible (7%) ---
Anesthetics and Drugs used during Anesthesia
Gallamine Considerable Considerable
Antianxiety Agents, Sedatives and Hypnotics
Buspirone Negligible ---
Chloral Hydrate Negligible ---
Ethchlorvynol Negligible ---
Glutethimide Negligible ---
Meprobamate Negligible ---
Methaqualone Negligible ---
Oxazepam Negligible ---
Phenobarbital Negligible ---
Zopiclone Negligible ---
Anticholinergics and Cholinergics
Cisapride Negligible ---
Metoclopramide Negligible ---
Pirenzipine 11-15% ---
Anticoagulants, Antifibrinolytics and Antiplatelet Agents
Warfarin Negligible Negligible
Low molecular weight heparins Negligible ---
Anticonvulsants
Gabapentin 50% ---
Ethosuximide 45% ---
Levetiracetam 25-50% ---
Phenytoin Negligible Negligible
Primidone 30% ---
Topiramate 50% ---
Valproic Acid Negligible (1%) Negligible
Antihistamines
Cetirizine --- Negligible (9%)
Cimetidine 10-20% Negligible (1.6%)
Famotidine Negligible (6-16%) Negligible (4.5%)
Fexofenadine Negligible (< 1.7%) ---
Levocabastine Negligible (11%) ---
Loratadine Negligible ---
Nizatidine Negligible (10%) ---
Ranitidine 50-60% Negligible (< 1%)
Anti-inflammatory Agents
Anakinra Negligible Negligible
Azapropazone Negligible Negligible
Bromfenac Negligible ---
Leflunomide Negligible Negligible
Lornoxicam Negligible ---
Nabumetone Negligible ---
Oxaprozin Negligible Negligible
Penicillamine 30% ---
Sulindac Negligible ---
Antimicrobial Agents
Aminoglycosides
Aminoglycosides 50% 20-50%
Spectinomycin 50% ---
Carbapenems
Biapenem 90% ---
Imipenem 80-90% Negligible
Meropenem 50-70% ---
Cephalosporins
Cefaclor 33% ---
Cefadroxil 50% ---
Cefamandole 50% Negligible (5%)
Cefazolin 50% 20%
Cefdinir --- Negligible (1.4-7.2%)
Cefipime 40-70% 26%
Cefixime Negligible (1.6%) Negligible
Cefmenoxime 16-51% Negligible (< 10%)
Cefmetazole 60% ---
Cefodizime 50% Negligible (15%)
Cefonicid Negligible Negligible (6.5%)
Cefoperazone Negligible Negligible
Ceforanide 20-50% Negligible
Cefotaxime 60% Negligible (5%)
Cefotetan Negligible (5-9%) ---
Defotiam 30-40% ---
Cefoxitin 50% Negligible
Cefpirome 32-48% Negligible (12%)
Cefpodoxime 50% ---
Cefprozil 55% ---
Cefroxadine 50% ---
Cefsulodin 60% ---
Ceftazidime 50% Negligible
Ceftibuten 39% ---
Ceftizoxime 50% Negligible (16%)
Ceftriaxone 40% Negligible (4.5%)
Cefuroxime --- 20%
Cephacetrile 50% ---
Cephalexin 50-75% 30%
Cephalothin 50% ---
Cephapirin 20% ---
Macrolide Antibiotics
Clindamycin Negligible Negligible
Dirithromycin Negligible ---
Lincomycin Negligible Negligible
Monobactams
Aztreoman 40% Negligible
Carumonam 51% ---
Moxalactam 30-50% Negligible (15-20%)
Nitroimidazoles
Metronidazole 45% Negligible (10%)
Ornidazole 42% Negligible (6%)
Tinidazole 40% ---
Oxaxolindiones
Linezolid 33% ---
Penicillins
Amdinocillin 32-70% Negligible (< 4%)
Amoxicillin 30% ---
Ampicillin 40% ---
Azlocillin 30-45% ---
Carbenicillin 50% ---
Cloxacillin Negligible ---
Dicloxacillin Negligible ---
Methicillin Negligible ---
Mezlocillin 20-25% 24%
Nafcillin Negligible ---
Oxacillin Negligible ---
Penicillin 50% ---
Piperacillin 30-50% ---
Temocillin 50% Negligible (6%)
Ticarcillin 50% Negligible
Polymyxins
Colistin Negligible Negligible
Quinolones
Ciprofloxacin Negligible (2%) Negligible (0.4-1.6%)
Enoxacin Negligible ---
Fleroxacin Negligible (3-7%) Negligible (< 10%)
Gatifloxacin Negligible (14%) Negligible (11%)
Levofloxacin Negligible Negligible
Lomefloxacin Negligible ---
Norfloxacin Negligible ---
Ofloxacin Negligible (12-15%) Negligible (4-6%)
Pefloxacin --- Negligible
Temafloxacin Negligible (9.4%) ---
Streptogramins
Quinupristin-dalfopristin --- Negligible
Sulfonamides
Sulfamethoxazole 50% Negligible (8%)
Trimethoprim 50% Negligible (7%)
Tetracyclines
Doxycycline Negligible Negligible
Minocycline Negligible Negligible
Vancomycin Negligible Negligible (15-20%)
Teicoplanin Negligible Negligible (5%)
Antifungals
Amphotericin B Negligible ---
Fluconazole 40% Negligible (18%)
Flucytosine 50% ---
Itraconazole Negligible Negligible
Ketoconazole Negligible Negligible
Miconazole Negligible Negligible
Antimalarials
Choloroquine Negligible ---
mefloquine Negligible ---
Quinine Negligible ---
Antituberculous Agents
Para-aminosalicylic Acid 50% ---
Ethambutol Negligible (12%) ---
Isoniazid 75% ---
Antiviral Agents
Abacavir 24% ---
Acyclovir 60% Negligible (< 10%)
Amantadine Negligible ---
Cidofovir 50% Negligible
Didanosine 20-67% Negligible
Foscarnet 27-58% ---
Ganciclovir Negligible ---
Lamivudine Negligible ---
Ribavirin Negligible (8%) ---
Vidarabine 50% ---
Zidovudine Negligible Negligible
Antineoplastics and Antimetabolites
Cyclophosphamide 30-60% ---
Etoposide Negligible ---
Methotrexate Negligible ---
Paclitaxel Negligible ---
Antiulcer Agents
Lansoprazole Negligible ---
Omeprazole Negligible ---
Pantoprazole Negligible ---
Rabeprazole Negligible ---
Bronchodilators
Dyphylline 28% ---
Theophylline 40% ---
Zileuton Negligible (0.5%) ---
Cardiovascular Agents
Antianginal Agents
Amlodipine Negligible Negligible
Bepridil Negligible ---
Diltiazem --- Negligible (< 0.1%)
Felodipine Negligible ---
Isradipine Negligible ---
Nifedipine Negligible (< 1%) Negligible
Antiarrhythmics
N-acetylprocainamide 50% Negligible
Amiodarone Negligible ---
Bretylium Negligible ---
Cibenzoline Negligible ---
Disopyramide Negligible (2-4%) ---
Flecainide Negligible (1%) Negligible
Lorcainide Negligible (8-12%) ---
Mexiletine Negligible Negligible
Procainamide Negligible Negligible (< 5%)
Propafenone Negligible ---
Quinidine Negligible (< 1%) ---
Recainam Negligible (9%) ---
Sematilide 20-25% ---
Sotalol 40-57% ---
Tocainide 25% Negligible (2%)
Antihypertensives
  Alpha1-Adrenergic Antagonists
Doxazosin Negligible ---
Urapadil Negligible (6.5%) ---
  Angiotensin Antagonists
Candesartan Negligible (0.2%) ---
Erbesartan Negligible ---
Irbesartan Negligible ---
Losartan Negligible Negligible
  Beta-Adrenergic Antagonists
Acebutolol Negligible ---
Atenolol 50% ---
Carvedilol Negligible ---
Esmolol Negligible Negligible
Labetalol Negligible (2-5%) Negligible (0.14%)
Metoprolol Negligible ---
Nadolol 50% ---
Central Acting alpha2-Stimulants
Clonidine Negligible ---
Guanfacine Negligible ---
Converting Enzyme Inhibitors
Captopril 35-40% Negligible (< 1%)
Cilazapril Negligible (14%) ---
Enalapril 50% ---
Fosinopril --- Negligible (2%)
Lisinopril 50-60% ---
Omapatrilat Negligible ---
Perindopril 55% ---
Quinapril Negligible (5.4%) Negligible (2.6%)
Ramipril Negligible ---
Vasodilators
Buflomedil Negligible (3.4-6.7%) ---
Diazoxide Negligible ---
Ketansirin Negligible ---
Minoxidil 24-43% ---
Blood Lipid Lowering Agents
Bezafibrate Negligible Negligible (1.6%)
Clofibrate Negligible ---
Fenofibrate Negligible ---
Gemfibrozil Negligible ---
Pravastatin Negligible ---
Cardiac Inotropes
Digoxin Negligible Negligible (8%)
Fab Negligible Negligible
Hormonal Agents
Epoeitin --- Negligible (2.3%)
Hypoglycemic Agents
Repaglinide Negligible ---
Rosiglitazone Negligible ---
Hypourecemic Agents
Allopurinol 40% ---
Psychotherapeutic Agents
Citalopram Negligible (< 1%) ---
Lithium Considerable Considerable
Olanzapine Negligible ---
Sertindole Negligible (< 0.1%) ---
Sertraline Negligible ---
Tianeptine Negligible ---
Steroids
Prednisone Negligible ---
Miscellaneous
Cyclosporine Negligible ---
Mycophenolate Negligible ---
Sulbactam --- Negligible
Tazobactam 30-50% Negligible (11-13%)
Return to Main Index